Course Description

Medicinal chemistry is the application of chemistry in the context of human medicine. In this course students will gain an appreciation for the drug development process, together with brief introduction to the drug discovery and designing methods, and also deals with the chemistry of various class of drugs that act on different systems and organs of human body, which includes drugs acting on; autonomic nervous system, drugs acting on the central nervous system, Histamine and histamine antagonists, non-narcotic analgesics and drugs used in gout; cardiovascular drugs; pesticides; expectorants and antitussives; nonsteroidal and steroidal hormones, local and general anesthetics. The course is designed to provide an in-depth scientifically grounded and clinically relevant medicinal chemistry learning experience for pharmacy students.

Course Objectives

By the end of this course the students will able to understand methods employed in drug design, relationship between drugs and specific receptors, structures, reactions, synthesis, structural activity relationship, metabolism and degradation of selected groups of drugs like autonomic nervous system drugs, cardiovascular drugs, antihistamines, steroidal and non-steroidal hormone and related drugs.

Supporting objective

 Describe the basic concepts in medicinal chemistry,

 Describe the basic concepts of drug design (the drug discovery and development process), and the strategies to achieve it.

 To describe the chemical basis of drug absorption, distribution, metabolism and Elimination,

 To recognize the important functional groups that act as weak acids and bases and to recognize the molecular and environmental factors that influence their precise ionization profiles.

 To explore the fundamentals of drug metabolism (both biotransformation and conjugation pathways) through an identification of drug mechanisms that include the activation of some prodrugs.

 To describe the chemical basis of drug-target interactions.

 To explore the structure-activity concepts related to the presence of specific functional groups in agonist and antagonist drug structures.

 To understand the links with specific therapeutic applications for agonists and antagonists acting at specific drug receptors

 To develop the ability to recognize superior therapeutic drug mechanisms and properties of drugs

Course description:

This course is designed to enable graduate Pharmacists describe drugs used for treatment, diagnosis and prevention of diseases. Up on completion of this course, students will be able to explain the pharmacological actions, mechanism of actions, adverse reactions, therapeutic uses and pharmacokinetics of drugs affecting the nervous system, respiratory system, gastrointestinal system and autacoids. In addition to attending class room sessions, students will have the opportunity to work in Pharmacology Laboratory and will be able to practice selected basic experimental demonstration

Course objectives:

At the end of this course, students will be able to describe drugs acting on the nervous system, respiratory system, gastrointestinal system and explain autacoids and drug therapy of inflammation

Course description:

This course is designed to enable graduate Pharmacists describe drugs used for treatment, diagnosis and prevention of diseases. Up on completion of this course, students will be able to explain the pharmacological actions, mechanism of actions, adverse reactions, therapeutic uses and pharmacokinetics of drugs affecting the nervous system, respiratory system, gastrointestinal system and autacoids. In addition to attending class room sessions, students will have the opportunity to work in Pharmacology Laboratory and will be able to practice selected basic experimental demonstration

Course objectives:

At the end of this course, students will be able to describe drugs acting on the nervous system, respiratory system, gastrointestinal system and explain autacoids and drug therapy of inflammation

Course Description The course deals with the applications of important instrumental analytical techniques such as spectro-chemical methods including UV- Visible, atomic absorption, flame spectroscopy, mass spectroscopy and nuclear magnetic resonance spectroscopy; chromatographic methods including Gas Chromatography and High Performance Liquid Chromatography in quality controls of pharmaceutical products. The course has 16 weeks of practical classes in which different instrumental analytical techniques will be studied as employed in the estimation of the constituents of drugs included in the national drug list Course Objectives After completing this course, students will be able to understand the instrumentation of different modern instrumental analytical techniques and their use in pharmaceutical and biochemical analysis. They will also able to propose suitable analytical technique for a sample, carry out analysis for different pharmaceuticals as well as handle, interpret and report data obtained from the analysis. Supporting objectives  Describe UV-Visible spectroscopy  Describe infrared spectroscopy  Describe fluorescence spectroscopy  Describe atomic spectroscopy  Describe mass spectroscopy  Identify different chromatographic techniques  Describe gas chromatography  Describe high performance liquid chromatography  Describe biological methods of analysis

Course Description:

The design of the course is based on the integration of the study of physico-chemical principles of pharmacy with the formulation, preparation and stabilization of semisolid and solid pharmaceutical dosage forms. In line with this, the course deals with scientific principles related to thermodynamic and electrical properties of colloidal systems, and diffusion and dissolution theories associated with drug release kinetics from dosage forms. The module is also designed to enable students apply these theories and principles for the formulation and production of semisolid and solid dosage forms in the practical compounding sessions and thereafter during their professional career. The principles of drug degradation mechanisms, rate and kinetic theories of chemical reactions are also included for their application in the determination of product shelf-life and stability studies. The applications of pharmaceutics in cosmetics, overview of radiopharmaceuticals and veterinary dosage forms are also included.